STAT 600s

STAT 631 Introduction to Statistical Methods in Health Informatics (0.50) LECCourse ID: 013825
Exploratory data analysis and data visualization. Confounding, censoring, selection bias, study designs and meta-analysis. Statistical modelling for continuous and binary data. Use of a statistics package, such as SAS, to analyze case studies will be important throughout. This is open only to students registered in the Masters of Health Informatics plan.
Instructor Consent Required
Prereq: STAT 231
Also offered Online

STAT 690 Literature and Research Studies (0.50) RDGCourse ID: 010554
1 Computational Methods-Finance

STAT 800s

STAT 814 Systematic Review and Meta-Analysis (0.50) LEC,TUTCourse ID: 014953
(Cross-listed with PHARM 614)
This course will provide students with an overview of the rationale and stages involved in the conduct of a formal systematic review and meta-analysis of a well-defined clinical/health research question. The overarching aim is to provide students with the tools to critically appraise and conduct a systematic review and meta-analysis. Students will largely work in pairs to progress through each step involved (with feedback from instructors at each stage) and to produce a final systematic review and meta-analysis to be presented/submitted at the end of the course. Course Objectives: 1. To demonstrate an understanding of the rationale underlying a systematic review and meta-analysis and relevance to clinical care and health policy; 2. To critically appraise a systematic review; 3. To develop a focused research question amenable to a systematic review; 4. To develop and implement a comprehensive and systematic literature search strategy; 5. To determine and apply procedures for including/excluding potential studies for a systematic review and meta-analysis; 6. To develop and implement a data abstraction process and study database; 7. To demonstrate an understanding of the fundamental statistical/biostatistical issues relevant to the conduct of a formal systematic review and meta-analysis. 8. To perform statistical analyses for a systematic review and meta-analysis and complete/present a final report demonstrating all stages involved. Students will need to meet with Course Coordinators and provide of appropriate previous experience with linear and/or logistic regression techniques.
Instructor Consent Required

STAT 830 Experimental Design (0.50) LECCourse ID: 010065
Review of experimental designs in a regression setting; analysis of variance; replication, balance, blocking, randomization, and interaction; one-way layout, two-way layout, and Latin square as special cases; factorial structure of treatments; covariates; treatment contrasts; two-level fractional factorial designs; fixed versus random effects; split-plot and repeated-measures designs; other topics.
Antireq: STAT 430.

STAT 831 Generalized Linear Models and Applications (0.50) LECCourse ID: 003087
Review of normal linear regression and maximum likelihood estimation. Computational methods, including Newton-Raphson and iteratively reweighted least squares. Binomial regression; the role of the link function. Goodness-of-fit, goodness-of-link, leverage. Poisson regression models. Generalized linear models. Other topics in regression modelling.
Antireq: STAT 431.

STAT 833 Stochastic Processes (0.50) LECCourse ID: 003088
Random walks, renewal theory and processes and their application, Markov chains, branching processes, statistical inference for Markov chains.
Antirequisite: STAT 433.

STAT 835 Statistical Methods for Process Improvement (0.50) LEC,TUTCourse ID: 003089
Statistical methods for improving processes based on observational data. Assessment of measurement systems. Strategies for variation reduction. Process monitoring, control and adjustment. Clue generation techniques for determining the sources of variability. Variation transmission.
Antireq: STAT 435

STAT 836 Introduction to the Analysis of Spatial Data in Health Research (0.50) LECCourse ID: 014078
The objective of this course is to develop understanding and working knowledge of spatial models and analysis of spatial data. The course provides an introduction to the rudiments of statistaical inference based on spatially correlated data. Methods of estimation and testing will be developed for geostatistical models based on variograms and spatial autoregressive models. Concepts and application of methods will be emphasized through case studies and projects with health applications.
Prereq: STAT 431 or 831.
Antireq: STAT 436

STAT 837 Analysis of Longitudinal Data in Health Research (0.50) LECCourse ID: 014081
This course will provide an introduction to principles and methods for the analysis of longitudinal data. Conditional and random effect of modeling approaches to regression analysis will be covered, as well as semiparametric methods based on generalized estimating equations. The importance of model assessment and parameter interpretation will be emphasized. Problems will be motivated by applications in epidemiology, clinical medicine, health services research, and disease natural history studies. Students will be required to think critically about appropriate strategies for data analysis. Analysis will be carried out with appropriate statistical software.
Prereq: STAT 431 or 831.
Antireq: STAT 437

STAT 840 Computational Inference (0.50) LECCourse ID: 003090
(Cross-listed with CM 761)
Introduction to and application of computational methods in statistical inference. Monte Carlo evaluation of statistical procedures, exploration of the likelihood function through graphical and optimization techniques including EM. Bootstrapping, Markov Chain Monte Carlo, and other computationally intensive methods.
Antireq: CM 461; STAT 440

STAT 841 Statistical Learning - Classification (0.50) LECCourse ID: 003091
(Cross-listed with CM 763)
Given known group membership, methods which learn from data how to classify objects into the groups are treated. Review of likelihood and posterior based discrimination. Main topics include logistic regression, neural networks, tree-based methods and nearest neighbour methods. Model assessment, training and tuning.
Antireq: CM 463; STAT 441

STAT 842 Data Visualization (0.50) LECCourse ID: 012612
(Cross-listed with CM 762)
Visualization of high dimensional data including interactive methods directed at exploration and assessment of structure and dependencies in data. Methods for finding groups in data including traditional and modern methods of cluster analysis. Dimension reduction methods including multi-dimensional scaling, nonlinear and other methods.
Antireq: CM 462; STAT 442

STAT 844 Statistical Learning - Function Estimation (0.50) LECCourse ID: 003092
(Cross-listed with CM 764)
Methods for finding surfaces in high dimensions from incomplete or noisy functional information. Both data adaptive and methods based on fixed parametric structure will be treated. Model assessment, training and tuning.
Antireq: CM 464; STAT 444

STAT 850 Estimation and Hypothesis Testing (0.50) LEC,TUTCourse ID: 003094
Discussion of inference problems under the headings of hypothesis testing and point and interval estimation. Frequentist and Bayesian approaches to inference. Construction and evaluation of tests and estimators. Large sample theory of point estimation.
Antireq: STAT 450

STAT 854 Sampling Theory and Practice (0.50) LECCourse ID: 003097
Sources of survey error. Probability sampling designs, estimation and efficiency comparisons. Distribution theory and confidence intervals. Generalized regression estimation. Software for survey analysis.
Antireq: STAT 454.

STAT 890 Topics in Statistics (0.50) RDGCourse ID: 010555
1 Stat. Survey Design & Analysis
2 Gen Hyperbol Distr&Appl-Financ
3 Analysis of Missing Data
4 Spatial Statistics
5 Data Visualization
6 Analysis - Complex Survey Data
7 Stochastic Differential Eqtns
8 Statistcl Analysis & Computing
9 SPC Foundations
10 Analysis of Network Graph Data
11 The Grammar of Graphics
12 Stat Learning in Auto Eng
13 Applied Experimental Design
14 Compressive Sensing

STAT 891 Topics in Probability (0.50) RDGCourse ID: 010556

STAT 900s

STAT 901 Theory of Probability 1 (0.50) LECCourse ID: 003101
Probability measures, random variables as measurable functions, expectation, independence, characteristic functions, limit theorems, applications.

STAT 902 Theory of Probability 2 (0.50) LECCourse ID: 003102
Review of conditioning on sigma-fields; martingale theory (discrete and continuous-time) and applications; counting processes; Brownian motion; stochastic differential and integral equations and applications; general theory of Markov processes (including martingale problems and semigroup theory), diffusions; weak convergence of stochastic processes on function spaces; functional versions of the central limit theorem and strong laws; convergence of empirical processes.
Antireq: ECE 780

STAT 906 Computer Intensive Methods for Stochastic Models in Finance (0.50) LECCourse ID: 003104
Review of basic numerical methods. Simulation of random variables, stochastic processes and stochastic models in finance. Numerical solution of deterministic and stochastic differential equations. Valuation of complex financial instruments and derivative securities. Project and paper.

STAT 908 Statistical Inference (0.50) LECCourse ID: 003105
Principles of Inference: sufficiency, conditionality, and likelihood; examples and counter examples; conditional inference and ancillarity. Theory of Hypothesis Testing: Neyman-Pearson lemma; similar tests; invariant tests. Asymptotic Theory: maximum likelihood and related theory; large-sample properties of parametric significance tests. Interval Estimation: confidence intervals and significance intervals; location and scale models, conditional intervals. Introduction to Decision Theory: loss and risk functions, admissibility; minimax and Bayes rules; prior and posterior analysis. The course content of Stat 850 is a presumed prerequisite for Stat 908.

STAT 923 Multivariate Analysis (0.50) LECCourse ID: 003113
Multivariate problems as extensions of univariate problems, discriminant analysis, canonical correlation and principle component analysis.

STAT 929 Time Series 1 (0.50) LECCourse ID: 003116
Iterative model building. ARIMA models, application to forecasting, seasonal models, applications.

STAT 930 Time Series 2 (0.50) LECCourse ID: 003117
Multiple time series modeling including transfer function and intervention analysis. Various special topics in time series such as outliers, robustness, order determination methods, Kalman filtering, sampling and aggregation, seasonal adjustments.

STAT 931 Statistical Methods for the Design and Analysis of Epidemiological Studies (0.50) LECCourse ID: 014341
This course covers a wide range of topics pertaining to the design and statistical analysis of observational health studies. The course is divided into three areas: 1) classical epidemiological study designs including cross-sectional, cohort, population and family-based case-control studies, and issues related to selection of controls; 2) advanced epidemiological study designs including case-cohort, nested case-control, and multiphase sampling designs; 3) causal inference using propensity scores with matching, stratification and regression adjustments, marginal structural models, and instrumental variables. Studies will be discussed from the epidemiological literature and other sources in the public domain. Simulations and data analyses will be carried out using software (e.g. R or SAS). Students will be trained and assessed in part based on the preparation of reports and delivery of presentations.

STAT 932 Statistical Methods for the Design and Analysis of Randomized Intervention Trials (0.50) LECCourse ID: 014342
This course covers topics relevant for the design, conduct and analysis of clinical intervention trials. The statistical theory behind the methodology as well as practical issues will be discussed. The course is divided into three areas: 1) important methods for the design of randomized controlled trials including randomization techniques, sample size and power calculations, factorial designs, crossover designs, cluster-randomized trials, non-inferiority trials, adaptive designs, group sequential trials, and ethical issues in design and conduct of clinical trials; 2) topics of predictive modeling including ROC curves, explained variation, and biomarker analyses; 3) dealing with missing data in randomized trials through imputation and inverse weighting, missing covariates, non-compliance, contamination, unplanned crossover, and surrogate outcomes. Clinical trials from the medical literature and other sources in the public domain will be used as case studies for illustration. Simulations and data analyses will be carried out using statistical software (e.g. R or SAS). Students will be trained and assessed in part based on the preparation of reports and delivery of presentations.

STAT 935 Analysis of Survival Data (0.50) LECCourse ID: 003120
This course deals with methods of analyzing data on the time to failure with particular emphasis on the use of regression models for such data. Both parameteric and semi-parametric regression models will be considered.

STAT 938 Statistical Consulting (0.50) LECCourse ID: 003122
This course will cover some of the basic tools of a statistical consultant. Topics will include the use of statistical packages, problem-solving techniques, discussion of common statistical consulting problems, effective communication of statistical concepts and management of consulting sessions.

STAT 946 Topics in Probability and Statistics (0.50) LECCourse ID: 010557
Topics of current interest
Instructor Consent Required
1 Opt Portfolios in Cont Time
2 Non-parametric Models
3 Learning Ensembles of Models
4 Estimating Functions
5 Statistical Genetics
6 Comptnl Tools in Ruin & Que Th
7 Analysis of Longitudinal Data
8 Non-Paramtrc Rgrssn w/Applctns
9 Stat Analys of Incomplete Data
10 Neuroinformatics
11 Advncd Computational Inference
12 Spatial Statistics
13 Kernels & Ensembles
14 Machine Learning
15 Saddle point methods
16 Financial Econometrics
17 Applied Experimental Design
18 Probabalistic Graphical Models
19 Approximations in Statistics
20 Machine Learning
21 Analysis of Network Graph Data
22 Statistics in Policy
23 Analysis of Network Data
24 Statistics on Manifolds
25 Queueing Theory
26 Inference for Big Data
27 Empirical Likelihood
28 Mathematical Intro to Copulas
29 Stochastic Calculus
30 Deep Learning
31 Nonparametric Regression
32 An Introduction to Copulas
33 Finance Optimization Problems
34 Information Geometry
35 Graphical Models & Application
36 Stat Methods for Geonomic Data

STAT 947 Topics in Biostatistics (0.50) LECCourse ID: 010558
Topics of current interest
Instructor Consent Required
1 Analysis of Life History Data
2 Neuroinformatics
3 Event History Analysis
4 Analy Longitudinal Data Biosta
5 Measurement Error&Missing Data
6 Correlated Data Analysis
7 Missing data + Measrmnt error
8 Event History Methods
9 Measurement Error Models

STAT 974 Financial Econometrics (0.50) LECCourse ID: 014063
(Cross-listed with ACTSC 974)
The focus of this course is on the statistical modelling, estimation and inference and forecasting of nonlinear financial time series, with a special emphasis on volatility and correlation of asset prices and returns. Topics to be covered normally include: review on distribution and dynamic behaviour of financial time series, univariate and multivariate GARCH processes, long-memory time-series processes, stochastic volatility models, modelling of extreme values, copulas, realized volatility and correlation modelling for ultra high frequency data and continuous time models.